Translational Lab



Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice Sánchez-León CA, Sánchez-Garrido Campos G, Fernández M, Sánchez-López A, Medina JF, Márquez-Ruiz J.

bioRxiv 2023.02.18.529047; doi:


Electrophysiological alterations of the Purkinje cells and deep cerebellar nuclei neurons in a mouse model of Alzheimer’s disease. Cheron G, Ristori D, Márquez-Ruiz J, Cebolla AM, Ris L.

European Journal of Neuroscience, 2022., 1– 17.


Altered cerebellar response to somatosensory stimuli in the Cntnap2 mouse model of autism. Fernández M, Sánchez-León CA, Llorente J, Sierra-Arregui T, Knafo S, Márquez-Ruiz J, Peñagarikano O.

eNeuro, 2021. ENEURO.0333-21.2021. doi: 10.1523/ENEURO.0333-21.2021.

Cortical circuitry and synaptic dysfunctions in Alzheimer’s Disease and other dementias. Ranieri F, Benussi A, Cantone M, Ferreri F, Márquez-Ruiz J.

Neural Plasticity, 2021. 9796576. doi: 10.1155/2021/9796576.

Impact of chronic transcranial Random Noise Stimulation (tRNS) on GABAergic and glutamatergic activity markers in the prefrontal cortex of juvenile mice. Sánchez-León CA, Sánchez-López A, Gómez-Climent MA, Cordones I, Cohen Kadosh R, Márquez-Ruiz J.

Progress in Brain Research, 2021. 264:323-341. doi: 10.1016/bs.pbr.2021.01.017.

Immediate and after effects of transcranial direct-current stimulation in the mouse primary somatosensory cortex. Sánchez-León CA, Cordones I, Ammann C, Ausín JM, Gómez-Climent MA, Carretero-Guillén A, Sánchez-Garrido Campos G, Gruart A, Delgado-García JM, Cheron G, Medina JF, Márquez-Ruiz J.

Scientific Reports, 2021. 11, 3123. 


Drug-responsive Inhomogeneous Cortical Modulation by Direct Current Stimulation Sun Y, Dhamne SC, Carretero-Guillén A, Salvador R, Goldenberg MC, Godlewski BR, Pascual-Leone, Madsen JR, Stone SSD, Ruffini G, Márquez-Ruiz J, Rotenberg A.

Annals of Neurology, 2020. 88:489-502. doi: 10.1002/ana.25822. 


Exploring new transcranial electrical stimulation strategies to modulate brain function in animal models Sánchez-León CA, Sánchez-López A, Ammann C, Cordones I, Carretero-Guillén A, Márquez-Ruiz J. 

Current Opinion in Biomedical Engineering, 2018. 8:7-13.

Using animal models to improve the design and application of transcranial electrical stimulation in humans Sánchez-León CA, Ammann C, Medina JF, Márquez-Ruiz J.

Current Behavioral Neuroscience Reports, 2018. 5:125–135.

Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD Cheron G, Márquez-Ruiz J, Cheron J, Prigogine C, Ammann C, Lukowski R, Ruth P, Dan B.

Scientific Reports, 2018. 8(1):4220. doi: 10.1038/s41598-018-22654-6.


Modulating motor learning through transcranial direct-current stimulation: an integrative view Ammann C, Spampinato D, Márquez-Ruiz J. 

Front Psychol, 2016. 7:1981. doi: 10.3389/fpsyg.2016.01981

The motor cortex is involved in the generation of classically conditioned eyelid responses in behaving rabbits Ammann C, Márquez-Ruiz J, Gómez-Climent MA, Delgado-García JM, Gruart A.

J Neurosci, 2016. 36(26):6988 –7001

Synthetic tactile perception induced by transcranial alternating-current stimulation can substitute for natural sensory stimulus in behaving rabbits Márquez-Ruiz J, Ammann C, Leal-Campanario R, Ruffini G, Gruart A, Delgado-García JM. 

Scientific Reports, 2016. 6:19753. doi: 10.1038/srep19753.

Oscillations, Timing, Plasticity, and Learning in the Cerebellum Cheron G, Márquez-Ruiz J, Dan B.

Cerebellum. 2016. 15(2):122-38. doi:10.1007/s12311-015-0665-9


Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression Erkens M, Tanaka-Yamamoto K, Cheron G, Márquez-Ruiz J, Prigogine C, Schepens J, Kasri N, Augustine G, Hendriks W.

Molecular Brain. 2015. 8:1. doi:10.1186/s13041-014-0092-8


Disruption of the LTD dialogue between the cerebellum and the cortex in Angelman syndrome model: a timing hypothesis Cheron G, Márquez-Ruiz J, Kishino T, Dan B.

Front Syst Neurosci. 2014. doi:10.3389/fnsys.2014.00221

Transcranial electrical-current stimulation in animals. (Chapter book) Márquez-Ruiz J, Leal-Campanario R, Wendling F, Ruffini G, Gruart A, Delgado-García JM.

In: The stimulated Brain: Cognitive Enhancement Using Non-Invasive Brain Stimulation (R. Cohen Kadosh Ed.) Amsterdam: Elsevier. 2014. 117-143.

Emergence of a 600 Hz-buzz UP state Purkinje cell firing in alert mice Cheron G, Prigogine C, Cheron J, Márquez-Ruiz J, Traub RD, Dan B.

Neuroscience. 2014, 263:15-26.


Translational approach of behavioral learning: lessons from cerebellar plasticity Cheron G, Dan B, Márquez-Ruiz J.

Neural Plast. 2013, 2013:853654. doi:10.1155/2013/853654

The effect of transcranial direct current stimulation: a role for cortical excitation/inhibition balance? Krause B, Márquez-Ruiz J, Cohen Kadosh R.

Front Hum Neurosci. 2013, 7:602. doi:2013.00602

Effects of transcranial Direct Current Stimulation (tDCS) on cortical activity: A computational modeling study. Molaee-Ardekani B, Márquez-Ruiz J, Merlet I, Leal-Campanario R, Gruart A, Sánchez-Campusano R, Birot G, Ruffini G, Delgado-García JM, Wendling F.

Brain Stimul. 2013, 6:25-39


Sensory stimulation-dependent plasticity in the cerebellar cortex of alert mice. Márquez-Ruiz J, Cheron G.

PLoS One. 2012 7(4): e36184. doi:10.1371/journal.pone.0036184

Transcranial direct-current stimulation modulates synaptic mechanisms involved in associative learning in behaving rabbits. Márquez-Ruiz J, Leal-Campanario R, Sánchez-Campusano R, Molaee-Ardekani B, Wendling F, Miranda PC, Ruffini G, Gruart A, Delgado-García JM. 

PNAS USA. 2012 Apr;109(17):6710-5.


Eye movements and abducens motoneuron behavior after cholinergic activation of the nucleus reticularis pontis caudalis. Márquez-Ruiz J, Escudero M.

Sleep. 2010 Nov;33(11):1517-27.


Eye movements and abducens motoneuron behavior during cholinergically induced REM sleep. Márquez-Ruiz J, Escudero M.

Sleep. 2009 Apr;32(4):471-81.

Where do we look while sleeping? Márquez-Ruiz J, Escudero M. 

Physiology News. 2009 Nº 75.


Tonic and phasic phenomena underlying eye movements during sleep in the cat. Márquez-Ruiz J, Escudero M.

J Physiol. 2008 Jul 15;586(14):3461-77.

Tonic inhibition and ponto-geniculo-occipital-related activities shape abducens motoneuron discharge during REM sleep. Escudero M, Márquez-Ruiz J.

J Physiol. 2008 Jul 15;586(14):3479-91.


Anatomical and pharmacological relationship between acetylcholine and nitric oxide in the prepositus hypoglossi nucleus of the cat: functional implications for eye-movement control. Márquez-Ruiz J, Morcuende S, Navarro-López Jde D, Escudero M.

J Comp Neurol. 2007 Jul 20;503(3):407-20.


A cholinergic synaptically triggered event participates in the generation of persistent activity necessary for eye fixation. Navarro-López Jde D, Alvarado JC, Márquez-Ruiz J, Escudero M, Delgado-García JM, Yajeya J.

J Neurosci. 2004 Jun 2;24(22):5109-18.